Fariba Mahmoodpoor; Seyed Hojjat Hosseini; Elham Ahmadian; Mohammadreza Ardalan; Koorosh Kamali; Saeed Sardari; Narjes Khavasi
Volume 4, Issue 3 , March 2022, , Pages 263-271
Abstract
Acute kidney injury (AKI) is a common problem in many clinical conditions associated with increased mortality and morbidity. AKI is a common complication of distinct chemotherapy drugs, ...
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Acute kidney injury (AKI) is a common problem in many clinical conditions associated with increased mortality and morbidity. AKI is a common complication of distinct chemotherapy drugs, including cisplatin. Cisplatin induces nephrotoxicity in 20-30 percent of patients by a single dose, which is also increased by prolonged and repeated doses. Plant-derived phytochemicals have been considered to show beneficial effects against several toxic conditions. Capparis spinosa encompasses high amounts of bioactive antioxidant components. Therefore the current study aimed to evaluate its seeds potential nephroprotective effects against cisplatin-induced nephrotoxicity in vivo. The protective effects of the seeds of this plant have rarly been evaluated before. In this study, 40 male Sprague Dawley rats with weights 230±20 gr in 8 groups were assessed: Control group, cisplatin single dose 7 mg/kg intraperitoneally injected group, high dose Capparis spinosa hydroalcoholic extract 200 mg/kg group, and 5 treatment groups with cisplatin 7 mg/kg IP single dose and different doses and days of treatment by extract (50 and 100 mg/kg of extract for 1 day and 12 days and one post-treatment group).
